Water → 6-Bromo-2,3-dihydro-1H-inden-5-ol
反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([OH:10])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.C1C(=O)N([Br:18])C(=O)C1.O>CN(C=O)C>[Br:18][C:7]1[CH:8]=[C:9]2[C:4]([CH2:3][CH2:2][CH2:1]2)=[CH:5][C:6]=1[OH:10]参加物
5
実験手順
To a solution of 5-indanol (6.32 g, 47 mmol) in DMF (20 mL) is added NBS (8.38 g, 47 mmol) and the mixture is stirred at ambient temperature for 1 h. Water is added and the mixture is then extracted with EtOAc. The organic layer is washed with 1N HCl solution and brine, dried with NaSO4 and concentrated to give the title compound and it is used in the next step without purification.
後処理
- extractionthe mixture is then extracted with EtOAc
- washThe organic layer is washed with 1N HCl solution and brine
- dry with materialdried with NaSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-80e32c6f877440b6b53e04d0a34f7e3b
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119666B2
反応ノート
読み込み中…