Hydroxylamine HCl → 3,4-difluoro-N'-hydroxybenzenecarboximidamide
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[C:5]#[N:6].[Cl-].[OH:12][NH3+:13].C(=O)(O)[O-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[C:4]([C:5](=[N:13][OH:12])[NH2:6])[CH:7]=[CH:8][C:9]=1[F:10]参加物
6
実験手順
1.0 g (7.2 mmol) of 3,4-difluorobenzonitrile was initially charged in 30 ml of ethanol, and a solution of 0.5 g (7.2 mmol) of hydroxylammonium chloride and 0.6 g (7.2 mmol) of sodium bicarbonate in 11 ml of water was added at RT. The reaction mixture was stirred at RT for 16 h, concentrated under reduced pressure and reacted without further purification.
後処理
- concentrationconcentrated under reduced pressure
- customreacted without further purification
出典と根拠
- ORDレコード
- ord-f318a85fe057494a808fb1f517fdf0ad
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119663B2
反応ノート
読み込み中…