Sodium Azide → (3-Azidopropyl)(triphenyl)phosphanium bromide

HRID 1644237ノート

反応式

HRID 1644237 の反応式
[Br-].[Br:2][CH2:3][CH2:4][CH2:5][P+:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N-:25]=[N+:26]=[N-:27].[Na+]>C(O)C.O>[Br-:2].[N:25]([CH2:3][CH2:4][CH2:5][P+:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[N+:26]=[N-:27]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 2723862(3-Bromopropyl)triphenylphosphonium bromide

生成物 1

HCID 53362697(3-Azidopropyl)(triphenyl)phosphanium bromide

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

(3-Bromo-propyl)-triphenyl-phosphonium bromide was dissolved in ethanol/water (1/1). To it sodium azide was added. The reaction mixture was heated up to reflux overnight. Solvents were removed by evaporation. The residue was extracted by dry ethanol. Filtered and evaporated to give crude (3-azido-propyl)-triphenyl-phosphonium bromide and was used directly for the next step reaction without further purification.

後処理

  1. temperatureThe reaction mixture was heated up
  2. temperatureto reflux overnight
  3. customSolvents were removed by evaporation
  4. extractionThe residue was extracted by dry ethanol
  5. filtrationFiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-cc8f7aa2bf48480faa0fc7fc7dede3d5
出典データセット
uspto-grants-2012_02
特許番号
US08124607B2

反応ノート

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