Pyridine → 5-bromo-N-(thiazol-2-yl)pyridine-2-sulfonamide

HRID 1644668ノート

反応式

HRID 1644668 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.N1C=CC=CC=1.[Br:13][C:14]1[CH:15]=[CH:16][C:17]([S:20](Cl)(=[O:22])=[O:21])=[N:18][CH:19]=1>>[Br:13][C:14]1[CH:15]=[CH:16][C:17]([S:20]([NH:1][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)(=[O:22])=[O:21])=[N:18][CH:19]=1

参加物

4

反応物 3

HCID 1049PyridineHCID 21552-AminothiazoleHCID 445580975-Bromopyridine-2-sulfonyl chloride

生成物 1

HCID 575512525-bromo-N-(thiazol-2-yl)pyridine-2-sulfonamide

実験手順

To 2-AMINOTHIAZOLE (0.29 g, 0.0029 mol) in Pyridine (2 mL, 0.02 mol) was added portionwise 5-Bromo-pyridine-2-sulfonyl chloride (0.50 g, 0.0019 mol). The reaction mixture was stirred at room temperature for 24 h. The reaction mixture was concentrated under reduced pressure, diluted with Ethyl acetate, washed with 1.0 N HCl, H2O and brine, dried with anhydrous sodium sulfate, filtered and concentrated to give the product was obtained as a yellow solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additiondiluted with Ethyl acetate
  3. washwashed with 1.0 N HCl, H2O and brine
  4. dry with materialdried with anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give the product
  8. customwas obtained as a yellow solid

出典と根拠

ORDレコード
ord-732c5ad9834d4e549b77dc9f1449d92f
出典データセット
uspto-grants-2012_02
特許番号
US08124610B2

反応ノート

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