Hydrochloric Acid → HCID 25154341、化合物

HRID 1644772ノート

反応式

HRID 1644772 の反応式
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:22])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)=[O:22]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 251886012-(Acetyloxy)-N-[5-(methylsulfonyl)-2-thiazolyl]benzamide

生成物 1

HCID 25154341HCID 25154341、化合物収率 95.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 7 (1.0 g, 2.94 mmol, 1.0 eq) dissolved in THF (20 mL) was added under stirring to 2M HCl (100 mL). The reaction was refluxed for one hour and allowed to cool under stirring over one hour. The product was filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum ato afford 834 mg (95%) of 6 as a colorless solid.

後処理

  1. additionwas added
  2. temperatureThe reaction was refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product was filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum ato

出典と根拠

ORDレコード
ord-3750813336d04ea1988d86c9fdf3dd29
出典データセット
uspto-grants-2012_02
特許番号
US08124632B2

反応ノート

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