Triethylamine → 4-{5-[(4-Chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester

A mixture of 4-chloro-benzo[b]thiophene-2-carboxylic acid (98 mg, 0.462 mmol), CH2Cl2 (5 mL), and a catalytic amount of DMF was stirred under Ar, and oxalyl chloride (2M in dichloromethane, 600 μL, 1.20 mmol) was dripped into the mixture over 5 min. The mixture was stirred at room temperature and after 1.0 hr the reaction was concentrated to dryness. Benzene was added and the solution was evaporated to dryness again. The white-yellow solid was re-dissolved in 5 mL of CH2Cl2 and dripped, under Ar, into a solution of 4-(5-amino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (134 mg, 0.462 mmol), and triethylamine (102 μL, 1.0 mmol) in 5 mL of dichloromethane. The reaction was stirred at room temperature for 0.5 hr and then concentrated and the residue was taken up in 50 mL of EtOAc and washed with 50 mL of saturated ammonium chloride, brine and dried over anhydrous sodium sulfate. The EtOAc solvent was removed and the product was triturated with diethyl ether and hexanes (1:1 ratio), followed by filtration, to afford the product, 4-{5-[(4-chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester, as a pale green solid (80 mg, 38% yield). LCMS for C23H25ClN4O3S calcd. (m/e) 472, observed 471 (M−H).

1. concentrationwas concentrated to dryness
2. additionBenzene was added
3. customthe solution was evaporated to dryness again
4. dissolutionThe white-yellow solid was re-dissolved in 5 mL of CH2Cl2
5. stirringThe reaction was stirred at room temperature for 0.5 hr
6. concentrationconcentrated
7. washwashed with 50 mL of saturated ammonium chloride, brine
8. dry with materialdried over anhydrous sodium sulfate
9. customThe EtOAc solvent was removed
10. customthe product was triturated with diethyl ether and hexanes (1:1 ratio)
11. filtrationfollowed by filtration

ORDレコード

ord-d481a77e877d46e2834c8f8346292458

出典データセット

uspto-grants-2012_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08124766B2