関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Desbenzyl donepezil | HCID 10446897 | — |
| 触媒 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Donepezil | HCID 3152 | — |
反応手順
4-[(5,6-Dimethoxy-1-indanon-2-yl)methyl]piperidine (4 g) was taken in acetone (60 ml). To which benzyl chloride (1.92 g), potassium carbonate (2.28 g) and a catalytic quantity of tetrabutylammonium iodide (TBAI) were added. The reaction mixture was heated at 60° C. and reaction was monitored on TLC. Solvent was removed by distillation after reaction completion and the residue was taken in water and extracted with ethyl acetate (100 ml). The organic extract was acidified with cone. HCl. The solvent was evaporated under vacuum to yield the salt as a residue. Yield: 5.14 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08124783B2 |
|---|
| 出典データセット | uspto-grants-2012_02 |
|---|
| ORD ID | ord-7fca73cdba884ff9b8ca8b216c86ef8c |
|---|
| 出典メモ | uspto-grants-2012_02 |
|---|
