反应详情

温度

60 °C

4-[(5,6-Dimethoxy-1-indanon-2-yl)methyl]piperidine (4 g) was taken in acetone (60 ml). To which benzyl chloride (1.92 g), potassium carbonate (2.28 g) and a catalytic quantity of tetrabutylammonium iodide (TBAI) were added. The reaction mixture was heated at 60° C. and reaction was monitored on TLC. Solvent was removed by distillation after reaction completion and the residue was taken in water and extracted with ethyl acetate (100 ml). The organic extract was acidified with cone. HCl. The solvent was evaporated under vacuum to yield the salt as a residue. Yield: 5.14 g.

1. customreaction
2. customSolvent was removed by distillation
3. customafter reaction completion
4. extractionextracted with ethyl acetate (100 ml)
5. extractionThe organic extract
6. customThe solvent was evaporated under vacuum
7. customto yield the salt as a residue