Nitric Acid → 1-(5-Fluoro-2-nitrophenyl)ethan-1-one
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[N+:11]([O-])([OH:13])=[O:12]>>[CH3:9][C:8]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12])=[O:10]参加物
3
実験手順
m-Fluoroacetophenone (20.0 g, 0.14 mol) was cooled to below -5° C. and fuming nitric acid (100 cm3) added dropwise at such a rate that the temperature of the reaction mixture never exceeded -5° C. When the addition was complete the mixture was poured into ice/water. The precipitated yellow solid was filtered, washed with water and dried to give 5-fluoro-2-nitroacetophenone (21.4 g).
後処理
- additionWhen the addition
- filtrationThe precipitated yellow solid was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-9c18f6428602478591c758ecc0eec662
- 出典データセット
- uspto-grants-1993_01
- 特許番号
- US05176737
反応ノート
読み込み中…