4,4'-Dihydroxybiphenyl → 1,1'-Biphenyl, 4,4'-dimethoxy-

HRID 1646100

反応式

HRID 1646100 の反応式
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([Br:8])[CH:2]=1.O[C:10]1C=CC(C2C=C[C:19]([OH:22])=CC=2)=CC=1.Br[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1>>[CH3:10][O:7][C:6]1[CH:5]=[CH:4][C:3]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)=[CH:2][CH:1]=1.[Br:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:1][C:2]=1[C:19]([OH:22])=[O:30]

参加物

5

反応物 3

HCID 71124,4'-DihydroxybiphenylHCID 77304-BromoanisoleHCID 78084-Bromophenol

生成物 2

HCID 69402-Bromobenzoic acidHCID 164841,1'-Biphenyl, 4,4'-dimethoxy-収率 35%

実験手順

However, Busch et al. found that with aromatic compounds containing polar substituents, the selectivity to biphenyls was much lower. For example, p-bromophenol gave ca. 13.4% 4,4'-dihydroxybiphenyl, p-bromoanisole gave ca. 35% 4,4'-dimethoxybiphenyl, bromobenzoic acid gave 40% 4,4'-biphenyldicarboxylic acid and 3-bromobenzoic acid gave 56.5% 3,3'-biphenyldicarboxylic acid.

出典と根拠

ORDレコード
ord-6c322c571a7648399c8d3497427d5a68
出典データセット
uspto-grants-1993_01
特許番号
US05177258

関連ノート

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