Sodium Hydroxide → 2-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-ethoxy-3-methylbutanoic acid

HRID 1646141ノート

反応式

HRID 1646141 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH:12]([C:18]([O:21][CH2:22][CH3:23])([CH3:20])[CH3:19])[C:13]([O:15]CC)=[O:14])[N:4]=1.[OH-].[Na+]>C(O)C>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH:12]([C:18]([O:21][CH2:22][CH3:23])([CH3:19])[CH3:20])[C:13]([OH:15])=[O:14])[N:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 19801421HCID 19801421、化合物

生成物 1

HCID 157671522-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-ethoxy-3-methylbutanoic acid収率 85%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

That is, to Compound 50 (32.8 g, 0.1 mol) prepared in the above (1) dissolved in ethanol (100 ml) was added 5N sodium hydroxide (40 ml), and the mixture was stirred for one hour. Subsequently, ethanol was removed under reduced pressure, 5N hydrochloric acid (50 ml) was added to the residue obtained, and the residue was extracted with chloroform. The chloroform layer was washed with water and dried, and then chloroform was removed under reduced pressure to obtain 25.5 g (yield: 85.0%) of the title compound as white crystals.

後処理

  1. customSubsequently, ethanol was removed under reduced pressure, 5N hydrochloric acid (50 ml)
  2. additionwas added to the residue
  3. customobtained
  4. extractionthe residue was extracted with chloroform
  5. washThe chloroform layer was washed with water
  6. customdried
  7. customchloroform was removed under reduced pressure

出典と根拠

ORDレコード
ord-31250134ec8c416bbed180a23992cb78
出典データセット
uspto-grants-1993_01
特許番号
US05178663

反応ノート

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