Hydrochloric Acid → HCID 19800070、化合物

HRID 1646881ノート

反応式

HRID 1646881 の反応式
[ClH:1].[NH2:2][C:3]1[C:4]2[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=2[S:6][C:7]=1[N+:8]([O-])=O>C(O)C.[Pd]>[ClH:1].[NH2:8][C:7]1[S:6][C:5]2[CH:11]=[CH:12][CH:13]=[CH:14][C:4]=2[C:3]=1[NH2:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 32732623-Amino-2-nitro-benzo[b]thiophene

生成物 1

HCID 19800070HCID 19800070、化合物収率 101.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Fuming hydrochloric acid (1.92 ml, 24 mmol) was added to a suspension of 3-amino-2-nitrobenzo[b]thiophene (4.66 g, 24 mmol) (G. Van Zyl et al., Can. J. Chem., 44, 2283 (1966)) in 500 ml of 96% ethanol, and the mixture was hydrogenated in a Parr hydrogenation apparatus for 7 h at 40 psi and room temperature in the presence of 1 g of 5% palladium on carbon. The catalyst was filtered off under nitrogen, and the filtrate was evaporated to dryness to give 4.89 g (100%) of 2,3-diaminobenzo[b]thiophene hydrochloride, which was used in the next step without further purification.

後処理

  1. filtrationThe catalyst was filtered off under nitrogen
  2. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-0bac824f99ea43d8993245ed79641a4e
出典データセット
uspto-grants-1993_01
特許番号
US05182279

反応ノート

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