Pyridine → 2-(3-Methoxy-phenyl)-7-benzofurancarbaldehye

HRID 1646965ノート

反応式

HRID 1646965 の反応式
[OH:1][C:2]1[C:9](I)=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]#[CH:20])[CH:16]=[CH:17][CH:18]=1.N1C=CC=CC=1>C(OCC)(=O)C>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]2[O:1][C:2]3[C:3]([CH:4]=[O:5])=[CH:6][CH:7]=[CH:8][C:9]=3[CH:20]=2)[CH:16]=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 6407531-Ethynyl-3-methoxybenzeneHCID 152099202-Hydroxy-3-iodobenzaldehyde

生成物 1

HCID 149956822-(3-Methoxy-phenyl)-7-benzofurancarbaldehye収率 143%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 11 g of 2-hydroxy-3-iodo benzaldehyde, 8.6 g of (3-methoxy-phenyl) acetylene and 150 ml of pyridine was refluxed for 45 minutes and then allowed to return to ambient temperature. Ethyl acetate was added, and washing was carried out with an acid solution, followed by drying and concentrating to obtain 16 g of product which was chromatographed on silica (eluant: hexane-isopropyl ether (7-3)) to obtain 9 g of the desired product melting at 55° C. to 60° C.

後処理

  1. temperaturewas refluxed for 45 minutes
  2. customto return to ambient temperature
  3. washwashing
  4. customby drying
  5. concentrationconcentrating

出典と根拠

ORDレコード
ord-407160e13ca745139678545078a93ff1
出典データセット
uspto-grants-1993_01
特許番号
US05182295

反応ノート

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