HCID 15670670、化合物 → HCID 15680278、化合物
反応式
O[CH2:2][C:3]([NH:6][C:7]([C:9]1[C:10]([C:18]2[C:19]([C:27]([NH:29][C:30]([CH3:34])([CH2:32][OH:33])[CH3:31])=O)=[CH:20][CH:21]=[C:22]3[O:26][CH2:25][O:24][C:23]=23)=[C:11]2[O:17][CH2:16][O:15][C:12]2=[CH:13][CH:14]=1)=[O:8])([CH3:5])[CH3:4]>S(Cl)(Cl)=O>[CH2:25]1[O:24][C:23]2[C:18]([C:10]3[C:11]4[O:17][CH2:16][O:15][C:12]=4[CH:13]=[CH:14][C:9]=3[C:7]3[O:8][CH2:2][C:3]([CH3:5])([CH3:4])[N:6]=3)=[C:19]([C:27]3[O:33][CH2:32][C:30]([CH3:31])([CH3:34])[N:29]=3)[CH:20]=[CH:21][C:22]=2[O:26]1参加物
3
実験手順
N,N'-Bis(3-hydroxy-2-methylpropan-2-yl)-5,6-methylenedioxy-5',6'-methylenedioxy-2,2'-biphenyldicarboxamide (3 g) is added to thionyl chloride (20 ml), and the mixture is stirred at room temperature for 2 hours. The reaction mixture is distilled under reduced pressure to remove thionyl chloride, and the residue is dissolved in ethyl acetate. The solution is washed, dried and distilled to remove the solvent, and the residue is crystallized from diisopropyl ether to give 5,6-methylenedioxy-5',6'-methylenedioxy-2,2'-bis(4,4-dimethyl-4,5-dihydro-2-oxazolyl)biphenyl (2 g) as colorless crystal. M.p. 152°-154° C.
後処理
- distillation