Thionyl Chloride → 4-(Chloromethyl)-[1,3]dioxolo[4,5-c]pyridine

HRID 1647172ノート

反応式

HRID 1647172 の反応式
O[CH2:2][C:3]1[C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=[CH:5][N:4]=1.S(Cl)([Cl:14])=O.C(=O)([O-])O.[Na+]>C(Cl)Cl>[Cl:14][CH2:2][C:3]1[C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=[CH:5][N:4]=1

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 199264631,3-Dioxolo[4,5-C]pyridine-4-methanol

生成物 1

HCID 199264524-(Chloromethyl)-[1,3]dioxolo[4,5-c]pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Hydroxymethyl-3,4-methylenedioxypyridine (90 mg, 0.59 mmol) was dissolved in methylene chloride (10 ml) and thionyl chloride (240 mg, 2 mmol) was added. After 10 min at ambient temperature the mixture was hydrolysed with sodium hydrogen carbonate and the phases were separated. The organic phase was dried over sodium sulphate, filtered and concentrated under reduced pressure. Yield: 90 mg (88%) of the title compound (crude).

後処理

  1. customthe phases were separated
  2. dry with materialThe organic phase was dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-36292afafd164e378e21d66a54f93554
出典データセット
uspto-grants-1995_07
特許番号
US05430042

反応ノート

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