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Trifluoroacetic acid → 2-Amino-N-(1H-benzimidazol-2-ylmethyl)-3-methylpentanamide tris(trifluoroacetate)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | [1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester | HCID 67747066 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Amino-N-(1H-benzimidazol-2-ylmethyl)-3-methylpentanamide tris(trifluoroacetate) | HCID 22068508 | — |
反応手順
The title compound is prepared by the procedure of Example 2 using 0.588 g of product from Example 11 in 6 ml of methylene chloride and 1.3 g of trifluoroacetic acid (TFA). The resulting desired intermediate is used as is in the next reaction. The 1HNMR indicates the correct product with associated TFA molecules.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05430150 |
| 出典データセット | uspto-grants-1995_07 |
| ORD ID | ord-c1c35f840070428b904dbe90e280737a |
| 出典メモ | uspto-grants-1995_07 |