Hydrochloric Acid → 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(hydroxymethyl)quinoline hydrochloride

HRID 1647445

反応式

HRID 1647445 の反応式
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][C:18]=1[CH3:24])=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:25][O:26]C(=O)C1C=CC(OC)=CC=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[OH-].[Na+].[ClH:39]>CO.O>[ClH:39].[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][C:18]=1[CH3:24])=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:25][OH:26])(=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 199096773-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(4-methoxybenzoyloxymethyl)quinoline

生成物 1

HCID 199230143-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(hydroxymethyl)quinoline hydrochloride収率 62%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 3-butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(4-methoxybenzoyloxymethyl)quinoline (2.34 g, 4.8 mmol) and sodium hydroxide (0.38 g, 9.6 mmol) in methanol (50 ml) was heated at reflux for 30 minutes, then diluted with water and neutralised with dilute hydrochloric acid. The solid was filtered off and washed with water, then converted to the hydrochloride. Recrystallisation from aqueous ethanol gave 3-butyryl-4-(4-hydroxy-2-methylphenylamino)-8-(hydroxymethyl)quinoline hydrochloride (1.16 g, 62%), m.p. 167°-171°.

後処理

  1. temperatureat reflux for 30 minutes
  2. filtrationThe solid was filtered off
  3. washwashed with water
  4. customRecrystallisation from aqueous ethanol

出典と根拠

ORDレコード
ord-3166ce2ab0fc4aa18be4c3feb5149d35
出典データセット
uspto-grants-1995_07
特許番号
US05432182

関連ノート

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