Betamethasone → Cortisone

HRID 1647496

反応式

HRID 1647496 の反応式
C[C@@H:2]1[C@:19]([OH:28])([C:20]([CH2:22][O:23]P([O-])([O-])=O)=[O:21])[C@:18]2([CH3:29])[C@H:4]([C@H:5]3[C@:15](F)([C@@H:16]([OH:30])[CH2:17]2)[C@:14]2([CH3:32])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[CH2:7][CH2:6]3)[CH2:3]1.[Na+].[Na+].C[C@@H]1[C@](O)(C(CO)=O)[C@]2(C)[C@H]([C@H]3[C@](F)([C@@H](O)C2)[C@]2(C)C(=CC(C=C2)=O)CC3)C1>>[CH3:32][C@@:14]12[C@H:15]3[C:16]([CH2:17][C@:18]4([CH3:29])[C@@:19]([OH:28])([C:20]([CH2:22][OH:23])=[O:21])[CH2:2][CH2:3][C@H:4]4[C@@H:5]3[CH2:6][CH2:7][C:8]1=[CH:9][C:10](=[O:11])[CH2:12][CH2:13]2)=[O:30]

参加物

3

反応物 2

HCID 9782BetamethasoneHCID 65478Betamethasone Sodium Phosphate

生成物 1

HCID 222786Cortisone

実験手順

Eight rabbits of the New Zealand breed were used, weighing approximately 2 kg. In the right eye of each animal, 0.8 ml/week of Bentelan Depot (equivalent to 4 mg betametasone) were instilled for 4 weeks. The left eye was kept as control. The medicament, administered subconjunctivally, brought about an increase of the intraocular tension in the first week, reached its peak in the second week and then remained constant until the fifth week.

後処理

  1. temperaturean increase of the intraocular tension in the first week
  2. customremained constant until the fifth week

出典と根拠

ORDレコード
ord-70b5c18eb54b4ea8b71d3e7b615800eb
出典データセット
uspto-grants-1995_07
特許番号
US05432199

関連ノート

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