Betamethasone Sodium Phosphate (HCID 65478)

名称と識別子

優先名称: Betamethasone Sodium Phosphate
IUPAC: disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
現地名: りん酸ベタメタゾンナトリウム
英語名: Betamethasone 21-phosphate disodium
分子式: C22H28FNa2O8P
分子量: 516.4

名称と別名

151-73-5Betamethasone sodium phosphateBetamethasone disodium phosphateBetamethasone 21-disodium phosphateBetamethasone 21-phosphate disodiumBetamethasone 21-phosphate disodium saltBetamethazone disodium phosphateDTXSID80471377BK02SCL3W9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate)NSC-90616CHEBI:3078

名称をさらに表示

サンベタゾン9-フルオロ-11β,17,21-トリヒドロキシ-16β-メチルプレグナ-1,4-ジエン-3,20-ジオン21-りん酸ジナトリウムステロネマベトネゾール9-フルオロ-11β,17-ジヒドロキシ-16β-メチル-21-[ビス(ソジオオキシ)ホスフィニルオキシ]プレグナ-1,4-ジエン-3,20-ジオンベンタランベタメタゾンホスファートナトリウムリンベタPFベタメタゾンリン酸エステルナトリウムハイコートりん酸ベタメタゾンナトリウムリノロサールソリューゾンベルベゾロンベタメタゾン21-りん酸二ナトリウム21-りん酸Βメタゾン二ナトリウム塩ベタメタゾン21-りん酸ナトリウムナトリウムりん酸Βメタゾンベタメタゾン 21-ホスファート二ナトリウムベタメタゾンリン酸エステルナトリウム (JP17)DurabetasonbetnesolbentelanCelestanBentalanNSC 90616Vista-Methasone

DTXCID6027137Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-betamethason sodium phosphateVistamethasoneBetam-ophtalVistamethasone nNSC90616RefChem:54528

データベース識別子

CAS: 151-73-5
PubChem CID: 65478
DTXSID: DTXSID8047137
ChEMBL: CHEMBL1200762
ChEBI: CHEBI:3078
UNII: 7BK02SCL3W
EC Number: 205-797-0
Nikkaji: J7.409H

物性

構造計算による物性

極性表面積: 147 Å²
水素結合供与体数: 2
水素結合受容体数: 9
回転可能結合数: 3
重原子数: 34
形式電荷: 0
複雑度: 961

物理化学的性質

融点: 206 · 206-211°C
比旋光度: 98 · +98.0~+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
貯蔵温度: room temp
溶解性: 96 %）に溶けにくく、ジクロロメタンにほとんど溶けない。 · 水に溶け、エタノール（96%）に溶けにくく、ジクロロメタンにほとんど溶けない。
外見: Solid
色: ホワイトからオフホワイト
PH: 7.5 · 7.5~9.0(5g/l, 25℃)
水溶解度: 50 mg/mL, · water: 50mg/mL, clear to very slightly hazy, faintly yellow
Merck: 14 · 14,1180
安定性: 吸湿性
InChIKey: PLCQGRYPOISRTQ-LWCNAHDDSA-L
SMILES: [C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r|
EPAの化学物質情報: .beta.-Methasone disodium phosphate (151-73-5)

化学的性質

化学的特性White or almost white powder, very hygroscopic.

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H302 (44.2%): Harmful if swallowed [Warning Acute toxicity, oral]；H330 (54.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]；H360 (42.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]；H360D (15%): May damage the unborn child [Danger Reproductive toxicity]；H372 (48.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H373 (12.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]；H410 (46.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P271, P273, P280, P284, P301+P317, P304+P340, P316, P318, P319, P320, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 113 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety Information · 1 件

IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Environment tier I assessment；IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Human health tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (44.2%)；Acute Tox. 2 (54.9%)；Repr. 1B (42.5%)；Repr. 1B (15%)；STOT RE 1 (48.7%)；STOT RE 2 (12.4%)；Aquatic Chronic 1 (46.9%)

法規制情報

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk: 3
rtecs: TU4056500
毒性: LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90
hs_code: 29372290
risk_code: 22
化審法: (9)-1520
hazard_code: Xn
safety_code: 36
Hazard Classifications: Acute Tox. 4 OralRepr. 1BSTOT RE 2
ストレージクラス: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

化学と産業

薬理情報

MeSH Pharmacological Classification · 1 件

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

用途と製造

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

応用分野

用途副腎皮質ホルモン剤です。糖質コルチコイドの 16α 位にメチル基が付加することで、電解質作用抑制作用を示します。鉱質コルチコイド作用を弱めた性質を有しています。

サプライヤー50 社

北京华美互利生物化工010-56205725 · [email protected]

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上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

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广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

補足説明

定義ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

りん酸ベタメタゾンナトリウム

基本情報