5-Methylthiazole → 5-Methyl-3-[[3-[[4-(tetradecyloxy)benzoyl]amino]phenyl]methyl]thiazolium bromide

HRID 1647584ノート

反応式

HRID 1647584 の反応式
[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:32])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][CH:12]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:33][C:34]1[S:38][CH:37]=[N:36][CH:35]=1>C1(C)C=CC=CC=1>[Br-:1].[CH3:33][C:34]1[S:38][CH:37]=[N+:36]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][C:10](=[O:32])[C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][CH:12]=3)[CH:4]=2)[CH:35]=1

参加物

4

反応物 2

HCID 1379805-MethylthiazoleHCID 11755784N-[3-(Bromomethyl)phenyl]-4-(tetradecyloxy)benzamide

生成物 1

HCID 101001345-Methyl-3-[[3-[[4-(tetradecyloxy)benzoyl]amino]phenyl]methyl]thiazolium bromide収率 91.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 4 g of N-[3-(bromomethyl)phenyl]-4-(tetradecyloxy)benzamide and 3.95 g of 5-methylthiazole in 50 ml of toluene is refluxed under argon for 4 hours. The solvent is removed and ether added to the residue. The solid is collected by centrifugation and washed several times with ether then vacuum dried to give 4.4 g of the desired product as a white powder, m.p. 188°-192° C.

後処理

  1. temperatureis refluxed under argon for 4 hours
  2. customThe solvent is removed
  3. additionether added to the residue
  4. customThe solid is collected by centrifugation
  5. washwashed several times with ether
  6. customvacuum dried

出典と根拠

ORDレコード
ord-0223dd2e0974443a814545f20ff4b29d
出典データセット
uspto-grants-1995_07
特許番号
US05432189

反応ノート

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