Acetone → HCID 131719041、化合物

HRID 1647764ノート

反応式

HRID 1647764 の反応式
[CH3:1][CH:2]([CH3:35])[CH2:3][O:4][C:5](=[O:34])[CH2:6][NH:7][C:8](=[O:33])[C@H:9]([CH2:17][N:18]1[CH2:23][CH2:22][C@:21]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([OH:31])[CH:26]=2)([CH3:24])[C@@H:20]([CH3:32])[CH2:19]1)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:36]([OH:44])(=[O:43])[C@H:37]([CH2:39][C:40]([OH:42])=[O:41])[OH:38].[CH3:45]C(C)=O>C(OCC)(=O)C>[C:36]([OH:44])(=[O:43])[CH:37]([CH2:39][C:40]([OH:42])=[O:41])[OH:38].[CH3:45][CH:3]([O:4][C:5](=[O:34])[CH2:6][NH:7][C:8](=[O:33])[C@H:9]([CH2:17][N:18]1[CH2:23][CH2:22][C@:21]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([OH:31])[CH:26]=2)([CH3:24])[C@@H:20]([CH3:32])[CH2:19]1)[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:2][CH3:1].[C:36]([OH:44])(=[O:43])[CH:37]([CH2:39][C:40]([OH:42])=[O:41])[OH:38].[C:36]([OH:44])(=[O:43])[CH:37]([CH2:39][C:40]([OH:42])=[O:41])[OH:38].[OH:31][C:27]1[CH:26]=[C:25]([C@:21]2([CH3:24])[CH2:22][CH2:23][N:18]([CH2:17][C@H:9]([CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]([NH:7][CH2:6][C:5]([O:4][CH:3]([CH3:36])[CH2:2][CH3:35])=[O:34])=[O:33])[CH2:19][C@@H:20]2[CH3:32])[CH:30]=[CH:29][CH:28]=1

参加物

5

反応物 3

HCID 180AcetoneHCID 222656L-Malic Acid2 回HCID 9871231HCID 9871231、化合物

生成物 1

HCID 131719041HCID 131719041、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
70 °C

実験手順

A compound of Example 1, (2.5 g, 5.2 mmol, 1.0 equiv) was dissolved in 50 mL of ethyl acetate. L-malic acid (1.03 g, 7.8 mmol, 1.5 eq) was added to the mixture. After the L-malic acid was dissolved by stirring, the solution was heated to 70° C. and 4.0 mL of acetone was added. The solution was crystallized. The product was isolated by filtration. The filter cake was washed with ethyl acetate. The salt was dried until the ethyl acetate levels were below 1%. The title compound was isolated as a white crystal. The sample was analyzed using x-ray powder diffraction. mp 94°-950C.

後処理

  1. customThe solution was crystallized
  2. customThe product was isolated by filtration
  3. washThe filter cake was washed with ethyl acetate
  4. dry with materialThe salt was dried until the ethyl acetate levels

出典と根拠

ORDレコード
ord-18b0787fd8154d95a574992f90ab913a
出典データセット
uspto-grants-1995_07
特許番号
US05434171

反応ノート

読み込み中…