Formaldehyde → N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

HRID 1648188ノート

反応式

HRID 1648188 の反応式
[CH3:1][C:2]([NH2:12])([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[CH:5]=1)[CH3:3].C=O.[C:15](=O)([O-])O.[Na+]>>[CH2:15]=[N:12][C:2]([CH3:1])([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[CH:5]=1)[CH3:3]

参加物

4

反応物 3

HCID 712FormaldehydeHCID 516892Sodium BicarbonateHCID 111950522-(3,5-Dichlorophenyl)propan-2-amine

生成物 1

HCID 21223286N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

実験手順

1-Methyl-1-(3,5-dichlorophenyl)ethylamine (7.5 g) was added slowly to formalin (aqueous 37% HCHO solution) (4.6 g) at room temperature. This was allowed to react as it was for 7 hours. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, which was then extracted with ether. After it was washed with saturated saline, the organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the captioned compound (8.6 g) as white crystals.

後処理

  1. customto react as it
  2. extractionwas then extracted with ether
  3. washAfter it was washed with saturated saline
  4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-3781e17054a34c25bde8dbf85febe0bc
出典データセット
uspto-grants-1995_07
特許番号
US05436224

反応ノート

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