3-(3,4-Dichlorophenyl)propionic acid → 5,6-Dichloro-2,3-dihydro-1H-inden-1-one
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[Cl:8]>S(Cl)(Cl)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[C:11](=[O:13])[CH2:10][CH2:9]2参加物
3
反応条件
- 温度
- 50 °C
実験手順
A mixture of 20 g of 3-(3,4-dichlorophenyl)-propionic acid [J. Med. Chem., Vol. 16(2) (1973), p. 101-106] and 100 ml of thionyl chloride was refluxed for 30 minutes and the thionyl chloride was then evaporated. The residue was taken up in 20 ml of methylene chloride and the solution was poured into a suspension of 20 g of aluminum chloride in 150 ml of methylene chloride. The mixture was stirred for one hour at room temperature and 30 minutes at 50° C. The mixture was poured over ice and was stirred for 30 minutes and then was extracted with methylene chloride.
後処理
- temperaturewas refluxed for 30 minutes
- customthe thionyl chloride was then evaporated
- additionthe solution was poured into a suspension of 20 g of aluminum chloride in 150 ml of methylene chloride
- additionThe mixture was poured over ice
- stirringwas stirred for 30 minutes
- extractionwas extracted with methylene chloride
出典と根拠
- ORDレコード
- ord-7b5fe474e06f46448b42d582990bfb06
- 出典データセット
- uspto-grants-1995_07
- 特許番号
- US05436244
反応ノート
読み込み中…