Sodium borohydride → 5,6-Dichloro-2,3-dihydro-1H-inden-1-OL
反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[Cl:13])[C:9](=[O:14])[CH2:8][CH2:7]2>CO>[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[Cl:13])[CH:9]([OH:14])[CH2:8][CH2:7]2参加物
4
実験手順
4.85 g of sodium borohydride were added at 0° C. to a solution of 4 g of the product of Step A in 285 ml of methanol and after stirring for one hour, the methanol was evaporated. The residue was diluted with water and excess hydride was eliminated by addition of hydrochloric acid. The mixture was extracted with ethyl acetate and the organic phase was evaporated to dryness under reduced pressure to obtain the desired product melting at 84° C.
後処理
- customthe methanol was evaporated
- additionThe residue was diluted with water and excess hydride
- additionwas eliminated by addition of hydrochloric acid
- extractionThe mixture was extracted with ethyl acetate
- customthe organic phase was evaporated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-e751a6ba12794190a2fe77716432c82e
- 出典データセット
- uspto-grants-1995_07
- 特許番号
- US05436244
反応ノート
読み込み中…