Phosgene → 6-Chloroquinazoline-2,4(1H,3H)-dione

HRID 1648216

反応式

HRID 1648216 の反応式
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([NH2:9])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[C:12](Cl)(Cl)=[O:13]>O1CCCC1>[Cl:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:11][C:12](=[O:13])[NH:9][C:7]2=[O:8]

参加物

4

反応物 2

HCID 6371PhosgeneHCID 788762-Amino-5-chlorobenzamide

生成物 1

HCID 3039986-Chloroquinazoline-2,4(1H,3H)-dione

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 5-chloroanthranilamide (3.4 g)in tetrahydrofuran (50 mL) was added phosgene (16 mL, 1.93M solution in toluene) via an addition funnel. The reaction mixture was stirred at room temperature for 4 hours and then heated to reflux for another two hours. The reaction mixture was concentrated to a total volume about 10 mL. After cooling, the title compound (3.72 g) having the following physical data, was collected by filtration and dried in vacuum.

後処理

  1. temperatureheated
  2. temperatureto reflux for another two hours
  3. concentrationThe reaction mixture was concentrated to a total volume about 10 mL
  4. temperatureAfter cooling
  5. filtrationwas collected by filtration
  6. customdried in vacuum

出典と根拠

ORDレコード
ord-6c47f84f579245e3a259b7c032951650
出典データセット
uspto-grants-1995_07
特許番号
US05436233

関連ノート

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