1-Propanol → Allantoin

HRID 1648331

反応式

HRID 1648331 の反応式
[NH2:1][C:2]([NH2:4])=[O:3].S(=O)(=O)(O)O.[CH2:10]([OH:13])[CH2:11]C>>[CH:11]1([NH:1][C:2]([NH2:4])=[O:3])[NH:4][C:2](=[O:3])[NH:1][C:10]1=[O:13]

参加物

4

反応物 3

HCID 10311-PropanolHCID 1118Sulfuric AcidHCID 1176Urea

生成物 1

HCID 204Allantoin

実験手順

A mixture of 26.4 g of glyoxylic acid propyl ester propyl hemiacetal (0.15 mol), 30.0 g of urea (0.5 mol), 600 g of propanol and 7.5 g of 8% strength propanolic sulfuric acid was heated under reflux for 4 hours. Thereafter, the reaction had ended and the reaction mixture was cooled to room temperature, whereupon a colorless precipitate separated out, which was filtered off, washed with methanol and dried in vacuo at 50° C. 13.6 g, that is to say 42% of theory, of crystalline allantoin acid propyl ester were obtained by this reaction.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. customseparated out
  4. filtrationwhich was filtered off
  5. washwashed with methanol
  6. customdried in vacuo at 50° C

出典と根拠

ORDレコード
ord-44cffc00f6544dadbc4829efb5f40658
出典データセット
uspto-grants-1995_07
特許番号
US05436256

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