Potassium Carbonate → 2-[2-(Cyclopropylmethoxy)phenoxy]ethan-1-OL

HRID 1648388

反応式

HRID 1648388 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10][OH:11].[CH:12]1([CH2:15]Br)[CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH:12]1([CH2:15][O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[O:8][CH2:9][CH2:10][OH:11])[CH2:14][CH2:13]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 785192-(2-Hydroxyethoxy)phenolHCID 81503Bromomethylcyclopropane

生成物 1

HCID 199199282-[2-(Cyclopropylmethoxy)phenoxy]ethan-1-OL収率 114.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2-Hydroxy-1-(2-hydroxyethyloxy)benzene (4 g, 26.0 mmol), cyclopropylmethyl-bromide (5.0 g, 37.0 mmol), and potassium carbonate (5.0 g, 36.2 mmol) were combined in acetone (80 mL) and the mixture was refluxed for 18 hours. The mixture was cooled and filtered. The filtrate was evaporated and the residue was dissolved in ether. The solution was washed with water 2N sodium hydroxide, and then brine, and dried over magnesium sulfate. Evaporation gave 2-cyclopropylmethyloxy-1-(2-hydroxyethyloxy)benzene (6.2 g) as an oil.

後処理

  1. temperaturethe mixture was refluxed for 18 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customThe filtrate was evaporated
  5. dissolutionthe residue was dissolved in ether
  6. washThe solution was washed with water 2N sodium hydroxide
  7. dry with materialbrine, and dried over magnesium sulfate
  8. customEvaporation

出典と根拠

ORDレコード
ord-b36ddcb32ab947d8a48b447404b689d7
出典データセット
uspto-grants-1995_07
特許番号
US05436264

関連ノート

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