Benzylamine → cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

HRID 1648479

反応式

HRID 1648479 の反応式
[C:1]([N:9]1[CH2:13][C@@H:12]([O:14][CH2:15][CH2:16]OS(C2C=CC(C)=CC=2)(=O)=O)[C@H:11](Br)[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:29]([NH2:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>C1(C)C(C)=CC=CC=1>[C:1]([N:9]1[CH2:13][C@@H:12]2[C@@H:11]([N:36]([CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:16][CH2:15][O:14]2)[CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 86748810trans-1-Benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine

生成物 1

HCID 53682667cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

124 g (0.265 mol) of trans-1-benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine are heated with 86 g (0.3 mol) of benzylamine in 1.5 l of xylene under reflux overnight. The salts of the benzylamine are filtered off with suction, and the filtrate is concentrated.

後処理

  1. temperatureunder reflux overnight
  2. filtrationThe salts of the benzylamine are filtered off with suction
  3. concentrationthe filtrate is concentrated

出典と根拠

ORDレコード
ord-f7118a019860452588c7bb504451d752
出典データセット
uspto-grants-1995_07
特許番号
US05436334

関連ノート

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