化工社化工社 化学情報印刷レポート · 研究参考用
Benzylamine → cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | trans-1-Benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine | HCID 86748810 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane | HCID 53682667 | — |
反応手順
124 g (0.265 mol) of trans-1-benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine are heated with 86 g (0.3 mol) of benzylamine in 1.5 l of xylene under reflux overnight. The salts of the benzylamine are filtered off with suction, and the filtrate is concentrated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05436334 |
| 出典データセット | uspto-grants-1995_07 |
| ORD ID | ord-f7118a019860452588c7bb504451d752 |
| 出典メモ | uspto-grants-1995_07 |