N-(4-Nitrobenzoyl)-beta-alanine → N-(4-Aminobenzoyl)-beta-alanine

HRID 1648730

反応式

HRID 1648730 の反応式
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[O:9])=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[O:9])=[CH:16][CH:17]=1

参加物

5

反応物 2

HCID 591374N-(4-Nitrobenzoyl)-beta-alanineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 719629N-(4-Aminobenzoyl)-beta-alanine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A suspension of 15 g. finely powdered 4-nitrobenzoyl-β-alanine in 200 ml. ethanol was stirred in an atmosphere of hydrogen in the presence of 1 g. of palladium-charcoal (5%), while cooling gently. When the absorption of hydrogen had ceased, the reaction mixture was filtered and the filtrate concentrated to a small volume. Upon adding diethyl ether and cooling, 4-aminobenzoyl-β-alanine was obtained. The yield was 11.5 g.; m.p. 156°-158° C.

後処理

  1. additionA suspension of 15 g
  2. customWhen the absorption of hydrogen
  3. filtrationthe reaction mixture was filtered
  4. concentrationthe filtrate concentrated to a small volume
  5. additionUpon adding diethyl ether
  6. temperaturecooling

出典と根拠

ORDレコード
ord-5d0d7d473fa1422ba7376a1e74cf250c
出典データセット
uspto-grants-1983_11
特許番号
US04412992

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