3-Pyridinecarbonyl chloride, hydrochloride (1:1) → 4-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

HRID 1648747ノート

反応式

HRID 1648747 の反応式
[C:1]([C:5]1[CH:10]=[C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:8]=[CH:7][C:6]=1[OH:17])([CH3:4])([CH3:3])[CH3:2].Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>N1C=CC=CC=1>[C:19]([O:17][C:6]1[CH:7]=[CH:8][C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:10][C:5]=1[C:1]([CH3:4])([CH3:2])[CH3:3])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1

参加物

4

反応物 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 97946452-t-butyl-4-cyclohexylphenol

生成物 1

HCID 1985864-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
35 °C

実験手順

12 g (52 mmol) of 2-t-butyl-4-cyclohexylphenol and 10 g (56 mmol) of nicotinic acid chloride hydrochloride was mixed with 150 ml of dry pyridine and stirred for 48 hours at 35° C. After cooling precipitated pyridine hydrochloride was sucked off and the filtrate mixed with 75 ml of water. The precipitated raw product was freed from pyridine by washing with water and recrystallized from alcohol.

後処理

  1. temperatureAfter cooling
  2. customprecipitated pyridine hydrochloride
  3. additionthe filtrate mixed with 75 ml of water
  4. customThe precipitated raw product
  5. washby washing with water
  6. customrecrystallized from alcohol

出典と根拠

ORDレコード
ord-b97418d47680424a80a3cfb888d6e53d
出典データセット
uspto-grants-1983_11
特許番号
US04412998

反応ノート

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