Propyl isocyanate → HCID 13228803、化合物

HRID 1648768ノート

反応式

HRID 1648768 の反応式
[OH:1][NH:2][C:3]([CH:5]1[CH2:7][CH2:6]1)=[O:4].[CH2:8]([N:11]=[C:12]=[O:13])[CH2:9][CH3:10]>C(N(CC)CC)C.C(Cl)Cl>[CH2:8]([NH:11][C:12]([N:2]([O:1][C:12]([NH:11][CH2:8][CH2:9][CH3:10])=[O:13])[C:3]([CH:5]1[CH2:7][CH2:6]1)=[O:4])=[O:13])[CH2:9][CH3:10]

参加物

5

反応物 2

HCID 61033Propyl isocyanateHCID 9989224N-hydroxycyclopropanecarboxamide

生成物 1

HCID 13228803HCID 13228803、化合物

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 6344Dichloromethane溶媒

実験手順

N-hydroxycyclopropanecarboxamide (5.0 grams), n-propyl isocyanate (9.3 grams) and 5 drops of triethylamine were stirred at room temperature in about 100 ml of methylene chloride for about 12 hours. The reaction mixture was then concentrated leaving an oily residue which crystallized upon scratching. This solid was then recrystallized from a mixture of cyclohexane and isopropanol and dried. Upon drying, the desired N-((propylamino)carbonyl)-N-(((propylamino)carbonyl)-oxy)cyclopropanecarboxamide was obtained as a white solid, m.p. 76°-78° C.

後処理

  1. concentrationThe reaction mixture was then concentrated
  2. customleaving an oily residue which
  3. customcrystallized
  4. customThis solid was then recrystallized from a mixture of cyclohexane and isopropanol
  5. customdried
  6. customUpon drying

出典と根拠

ORDレコード
ord-852ccd5ecccd420cb879adc1a6e7f2c2
出典データセット
uspto-grants-1983_11
特許番号
US04413009

反応ノート

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