Thionyl Chloride → Ethyl (2-chloroethyl)-n-butylcarbamate

HRID 1648773ノート

反応式

HRID 1648773 の反応式
O[CH2:2][CH2:3][N:4]([CH2:10][CH2:11][CH2:12][CH3:13])[C:5](=[O:9])[O:6][CH2:7][CH3:8].S(Cl)([Cl:16])=O>C(Cl)Cl>[Cl:16][CH2:2][CH2:3][N:4]([CH2:10][CH2:11][CH2:12][CH3:13])[C:5](=[O:9])[O:6][CH2:7][CH3:8]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 54381911Ethyl (2-hydroxyethyl)-n-butylcarbamate

生成物 1

HCID 12238083Ethyl (2-chloroethyl)-n-butylcarbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

52 g of ethyl (2-hydroxyethyl)-n-butylcarbamate are placed in 125 ml of methylene chloride and treated dropwise with 41.6 g of thionyl chloride during 45 minutes at 20°-25° C. Then the mixture is allowed to react for an additional 1 hour at room temperature. After removing the solvent, the residue is distilled to yield pure ethyl (2-chloroethyl)-n-butylcarbamate; b.p. 91° C./0.07 Torr.

後処理

  1. customto react for an additional 1 hour at room temperature
  2. customAfter removing the solvent
  3. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-973f27da9d324ef5bd0f3d5e5b32d5cc
出典データセット
uspto-grants-1983_11
特許番号
US04413010

反応ノート

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