1H-1,2,4-Triazole → 58905-18-3

HRID 1648855ノート

反応式

HRID 1648855 の反応式
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[Na].N1C=NC=N1.[OH-:12].[Na+].O[C:15]1([Cl:25])[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][CH:16]1[CH2:17][CH2:18]Cl>O.CS(C)=O>[OH:12][CH:17]([C:16]1[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:15]=1[Cl:25])[CH2:18][N:1]1[CH:5]=[N:4][CH:3]=[N:2]1

参加物

7

反応物 4

HCID 92571H-1,2,4-TriazoleHCID 14798Sodium HydroxideHCID 204809262-Hydroxy-2,4-dichlorophenethyl chlorideHCID 454898221h-1,2,4-Triazole sodium salt

生成物 1

HCID 66285758905-18-3

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

To a dimethyl sulfoxide solution (50 ml) of sodium 1,2,4-triazole, generated from 3.25 g (0.047 m) of 1H-1,2,4-triazole, and 1.9 g (0.047 m) of sodium hydroxide, is added 10 g (0.045 m) of 2-hydroxy-2,4-dichlorophenethyl chloride dropwise at 110° under nitrogen. The reaction is stirred at 110° for 11/2 hours. The reaction mixture is poured into water and extracted with methylene chloride. The combined organic extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 8 g of product.

後処理

  1. extractionextracted with methylene chloride
  2. washThe combined organic extracts are washed with water
  3. dry with materialdried over MgSO4
  4. customSolvent is evaporated

出典と根拠

ORDレコード
ord-40fae1094b9f41868e6eb81d226888d2
出典データセット
uspto-grants-1983_11
特許番号
US04414210

反応ノート

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