Iodine → (2-Chloro-4,5-dihydroxyphenyl)phenylmethanone

HRID 1648891

反応式

HRID 1648891 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([O:8]C)[C:5]([O:10]C)=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13].ClC1C=CC(OC)=C(OC)C=1.C(Cl)(=O)C1C=CC=CC=1.II.N1C=CC=CC=1OC(=O)C1C=CC=CC=1>FC(F)(F)C(O)=O>[OH:8][C:6]1[C:5]([OH:10])=[CH:4][C:3]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:13])=[C:2]([Cl:1])[CH:7]=1

参加物

7

反応物 5

HCID 807IodineHCID 7412Benzoyl chlorideHCID 280484-Chloro-1,2-dimethoxybenzene2 回HCID 817610Pyridin-2-yl benzoateHCID 14118997(2-Chloro-4,5-dimethoxyphenyl)-phenylmethanone

生成物 1

HCID 20396978(2-Chloro-4,5-dihydroxyphenyl)phenylmethanone

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The afore-mentioned dihydroxyketone can also be obtained in two stages analogously to Example 9(a) and (b). The (2-chloro-4,5-dimethoxyphenyl)-phenylmethanone required for this purpose can be obtained by acylating 4-chloro-1,2-dimethoxybenzene with benzoyl chloride in the presence of iodine. It is easier to obtain, however, if one equivalent of 4-chloro-1,2-dimethoxybenzene is heated in a bomb tube at 150° for 2 hours with 1.1 equivalents of (2-pyridinyl)-benzoate in trifluoroacetic acid. After working up and demethylation in a manner analogous to Example 9(b), the desired (4,5-dihydroxy-2-chlorophenyl)phenylmethanone is obtained.

後処理

  1. customcan be obtained
  2. customto obtain

出典と根拠

ORDレコード
ord-1cfbe90795f343ae8c6a1dd7fae753a4
出典データセット
uspto-grants-1983_11
特許番号
US04414214

関連ノート

読み込み中…