Chloroacetyl chloride → 5-(Chloroacetyl)-8-hydroxy-2(1H)-quinolinone

HRID 1649008ノート

反応式

HRID 1649008 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH:8]=[CH:7]2.[Cl:13][CH2:14][C:15](Cl)=[O:16].[Cl-].[Al+3].[Cl-].[Cl-].[N+](C1C=CC=CC=1)([O-])=O>Cl>[Cl:13][CH2:14][C:15]([C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:12])[NH:10]2)=[O:16]

参加物

6

反応物 4

HCID 6577Chloroacetyl chlorideHCID 7416NitrobenzeneHCID 972508-hydroxyquinolin-2(1H)-oneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 132602995-(Chloroacetyl)-8-hydroxy-2(1H)-quinolinone

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
70 °C

実験手順

To a solution of 8-hydroxycarbostyril (27 g) and chloroacetyl chloride (37 ml) in ntirobenzene (250 ml) was added aluminum chloride (85 g) portionwise and the mixture was stirred at 70° C. for 20 hours. After adding 10% hydrochloric acid (500 ml), nitrobenzene was removed by steam distillation. After cooling, crystals which formed were collected by filtration, washed with 300 ml of hot water and recrystallized from methanol to give 4.0 g of 5-chloroacetyl-8-hydroxycarbostyril.

後処理

  1. customwas removed by steam distillation
  2. temperatureAfter cooling
  3. customcrystals which formed
  4. filtrationwere collected by filtration
  5. washwashed with 300 ml of hot water
  6. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-9044843f8cda477f8220d25a01ba982a
出典データセット
uspto-grants-1983_11
特許番号
US04414390

反応ノート

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