Diethyl Ether → N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

HRID 1649044ノート

反応式

HRID 1649044 の反応式
[NH:1]=[C:2]1[N:6]([CH3:7])[CH2:5][CH2:4][S:3]1.[C:8]1([N:14]=[C:15]=[S:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.CCOCC>C1C=CC=CC=1>[CH3:7][N:6]1[CH2:5][CH2:4][S:3][C:2]1=[N:1][C:15]([NH:14][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[S:16]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 7673Phenyl IsothiocyanateHCID 773183-Methyl-1,3-thiazolidin-2-imine

生成物 1

HCID 54546998N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea収率 75%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of 0.043 mole of 2-imino-3-methylthiazolidine and an equimolar amount of phenylisothiocyanate in 70 ml of dry benzene is refluxed under nitrogen for 2.5 hours. Some ether is added to the cooled reaction mixture and solids are filtered off, 9.8 g (90%). Recrystallization from acetonitrile-ether (1:1) gives 8.0 g (75%) of pure N-(3-methyl-2-thiazolidinylidene)-N'-phenylthiourea; m.p. 168.5°-170.5° C.

後処理

  1. filtrationare filtered off
  2. customRecrystallization from acetonitrile-ether (1:1)

出典と根拠

ORDレコード
ord-48d0ad4196374bd6a78daf7039b1f5b7
出典データセット
uspto-grants-1983_11
特許番号
US04414211

反応ノート

読み込み中…