Methyl iodide → HCID 70508978、化合物

HRID 1649045ノート

反応式

HRID 1649045 の反応式
[CH3:1][N:2]1[CH2:6][CH2:5][S:4][C:3]1=[N:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9].[I:17][CH3:18]>CC(C)=O>[IH:17].[CH3:1][N:2]1[CH2:6][CH2:5][S:4][C:3]1=[N:7][C:8]([S:9][CH3:18])=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 54546998N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

生成物 1

HCID 70508978HCID 70508978、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A suspension of 17.0 g (0.067 mole) of N-(3-methyl-2-thiazolidinylidene)-N'-phenylthiourea and 11.1 g (0.078 mole) of iodomethane in 350 ml of acetone is refluxed for one hour. The solution is cooled at room temperature overnight (about 16 hours) and solids are filtered off, 25.1 g (95.2%), m.p. 159.5°-161.5° C. Recrystallization from methanol-ether (1:1) gives pure methyl N-(3-methyl-2-thiazolidinylidene)-N'-phenylcarbamimidothioate hydroiodide; m.p. 163.5°-165° C.

後処理

  1. temperatureis refluxed for one hour
  2. filtrationare filtered off
  3. customRecrystallization from methanol-ether (1:1)

出典と根拠

ORDレコード
ord-0ee6710d7b214a5480747b4f63ea6684
出典データセット
uspto-grants-1983_11
特許番号
US04414211

反応ノート

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