Pyrrolidine → 4-(4-Chlorophenyl)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine

HRID 1649074ノート

反応式

HRID 1649074 の反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:3]=1.[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:3]=1

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 35252HCID 35252、化合物

生成物 1

HCID 131383024-(4-Chlorophenyl)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine収率 91.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-Amino-4-chloro-6-(4-chlorophenyl)-s-triazine (melting point 273° to 275° C.) (2.12 grams) and 2.5 grams of pyrrolidine were dissolved in 20 milliliters of dioxane, the mixture was heated to reflux for two hours with stirring, the reaction solution was evaporated to dryness in vacuo, diluted aqueous solution of sodium hydroxide was added to the residue, insoluble matters were collected by filtration, and washed with isopropyl alcohol to give 2.21 grams of 2-amino-4-pyrrolidino-6-(4-chlorophenyl)-s-triazine, melting point 217° to 219° C.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for two hours
  3. customthe reaction solution was evaporated to dryness in vacuo, diluted aqueous solution of sodium hydroxide
  4. additionwas added to the residue, insoluble matters
  5. filtrationwere collected by filtration
  6. washwashed with isopropyl alcohol

出典と根拠

ORDレコード
ord-a1d3c3a053cd4264ae08a49895a92783
出典データセット
uspto-grants-1983_11
特許番号
US04415570

反応ノート

読み込み中…