Thionyl Chloride → 7,8-Dihydroxychromone-3-carbonyl chloride

HRID 1649130ノート

反応式

HRID 1649130 の反応式
[OH:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([C:6](=[O:16])[C:7]([C:13](O)=[O:14])=[CH:8][O:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:19])=O>>[OH:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([C:6](=[O:16])[C:7]([C:13]([Cl:19])=[O:14])=[CH:8][O:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24386Thionyl Chloride2 回HCID 127658447,8-Dihydroxychromone-3-carboxylic acid

生成物 1

HCID 130830427,8-Dihydroxychromone-3-carbonyl chloride

実験手順

7,8-Dihydroxychromone-3-carboxylic acid (6.6 g) together with thionyl chloride (25 ml) were refluxed for one hour. Certain unreacted thionyl chloride remained in the reaction mixture was distilled off, and after addition of benzene to the residue, the mixture was again subjected to distillation. To the residue was added n-hexane to cause solidification of the residue. The solid matter thus formed was recovered by filtration. There was thus obtained the desired product (7.2 g).

後処理

  1. distillationwas distilled off
  2. additionafter addition of benzene to the residue
  3. distillationthe mixture was again subjected to distillation
  4. additionTo the residue was added n-hexane
  5. customThe solid matter thus formed
  6. filtrationwas recovered by filtration

出典と根拠

ORDレコード
ord-eda0203be4574cd69ed07fcc10cfb557
出典データセット
uspto-grants-1983_11
特許番号
US04415567

反応ノート

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