Sodium Hydroxide → 8-Amino-3,4-dihydro-2(1H)-quinolinone

HRID 1649205ノート

反応式

HRID 1649205 の反応式
C([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13317111HCID 13317111、化合物

生成物 1

HCID 133171138-Amino-3,4-dihydro-2(1H)-quinolinone収率 0.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

8-Acetylamino-3,4-dihydrocarbostyril (11.8 g, 57.8 mols) was suspended in 90 ml of 20% hydrochloric acid and the suspension was stirred while heating under reflux for 1 hours. The reaction mixture was poured into ice water and neutralized with 5 N sodium hydroxide followed by adjusting to pH of about 8. Crystals which precipitated were collected by filtration to give 7.87 g of 8-amino-3,4-dihydrocarbostyril.

後処理

  1. temperaturewhile heating
  2. temperatureunder reflux for 1 hours
  3. customCrystals which precipitated
  4. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-f5a947b5920741e381580035a8177c62
出典データセット
uspto-grants-1983_11
特許番号
US04415572

反応ノート

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