Sodium Hydroxide → 8-Aminoquinolin-2(1H)-one

HRID 1649206ノート

反応式

HRID 1649206 の反応式
C([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13317110HCID 13317110、化合物

生成物 1

HCID 133171128-Aminoquinolin-2(1H)-one収率 91.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

8-Acetylaminocarbostyril (21.5 g, 0.106 mol) was suspended in 190 ml of 20% hydrochloric acid and the suspension was stirred while heating under reflux for 1 hour. The reaction mixture was poured into ice water and neutralized with 5 N sodium hydroxide. Crystals which formed were collected by filtration to give 15.47 g of 8-aminocarbostyril.

後処理

  1. temperaturewhile heating
  2. temperatureunder reflux for 1 hour
  3. customCrystals which formed
  4. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-6d38258e6bc741be942b36a5bb376208
出典データセット
uspto-grants-1983_11
特許番号
US04415572

反応ノート

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