Bromoform → 2-Bromo-5,6-dichloro-3-nitropyrazine
反応式
C(ON=O)CC(C)C.[Cl:9][C:10]1[N:11]=[C:12]([N+:18]([O-:20])=[O:19])[C:13](N)=[N:14][C:15]=1[Cl:16].C(Br)(Br)[Br:22]>>[Br:22][C:13]1[C:12]([N+:18]([O-:20])=[O:19])=[N:11][C:10]([Cl:9])=[C:15]([Cl:16])[N:14]=1参加物
4
実験手順
To 4.8 g isoamylnitrite in 150 ml bromoform heated to 95°-100° is added portionwise 5.0 g 5,6-dichloro-3-nitro-pyrazinamine. The reaction mixture is heated at reflux for 18 hours. After cooling, the bromoform is removed in vacuo to give an oil which is chromatographed on silica gel. The initial component to elute is 5,6-dichloro-2-bromonitropyrazine, which is obtained (2.6 g) as a viscous oil.
後処理
- temperatureThe reaction mixture is heated
- temperatureat reflux for 18 hours
- temperatureAfter cooling
- customthe bromoform is removed in vacuo
- customto give an oil which
- customis chromatographed on silica gel
- washThe initial component to elute
- customwhich is obtained (2.6 g) as a viscous oil
出典と根拠
- ORDレコード
- ord-d6c1fbabf9d14d2680ff4e9bb4e34afb
- 出典データセット
- uspto-grants-1983_11
- 特許番号
- US04416882
反応ノート
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