Sodium borohydride → 6-[1-Hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril
反応式
[N:1]1([CH2:6][C:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)=[O:8])[CH:5]=[CH:4][N:3]=[CH:2]1.[BH4-].[Na+]>CO>[OH:8][CH:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]2)[CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1参加物
4
実験手順
A solution of 3.0 g of 6-(imidazol-1-ylacetyl)-3,4-dihydrocarbostyril (the preparation of which is given in Example 3) in 120 ml of methanol was reacted with 1.2 g of sodium borohydride in the same manner as shown in Preparation 2, and the product similarly isolated to give 6-[1-hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril, m.p. 182°-184°
後処理
- customas shown in Preparation 2
- customthe product similarly isolated
出典と根拠
- ORDレコード
- ord-e2a97beaa9eb44abbb9e21febed68157
- 出典データセット
- uspto-grants-1990_05
- 特許番号
- US04921862
反応ノート
読み込み中…