Sodium Hydroxide → 1-(2,4-Dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol

HRID 1649781

反応式

HRID 1649781 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[OH-:17].[Na+].[Cl:19][C:20]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:21]=1[O:22][CH2:23][CH2:24]Br>C1(C)C=CC=CC=1.[Cl-].C([N+](CCCCCCCCCCCC)(C)C)C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([O:17][CH2:24][CH2:23][O:22][C:21]1[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:20]=1[Cl:19])([OH:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 1388811-(2-Bromoethoxy)-2,4-dichlorobenzeneHCID 66285758905-18-3

生成物 1

HCID 540910161-(2,4-Dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol収率 35%

試薬・触媒・溶媒 2

HCID 8753Benzododecinium Chloride触媒HCID 1140Toluene溶媒

実験手順

12.95 g (0.05 mole) of 1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-1-ethanol are dissolved in 100 ml of toluene, and 100 ml of 40% strength sodium hydroxide solution and 1 ml of benzyl-dodecyl-dimethylammonium chloride are added. 13.5 g (0.05 mole) of 2,4-dichlorophenoxyethyl bromide are then added dropwise and the mixture is subsequently stirred at room temperature for 48 hours. The organic phase is separated off, washed with three 100 ml portions of saturated sodium chloride solution, dried over sodium sulphate and concentrated. The residue is taken up in 100 ml of diethyl ether, and crystallizes after the mixture has stood for a short time. 7.8 g (35% of theory) of 1-(2,4-dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol of melting point 88°-90° C. are obtained.

後処理

  1. customThe organic phase is separated off
  2. washwashed with three 100 ml portions of saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated
  5. customcrystallizes after the mixture

出典と根拠

ORDレコード
ord-4bd5082c1bf1429e8c2e90a042b4904b
出典データセット
uspto-grants-1990_05
特許番号
US04921870

関連ノート

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