Trifluoroacetic acid → 2(S)-(L-histidyl)amino-1-cyclohexyl-(S)-hydroxy-6-methylheptane

HRID 1649921ノート

反応式

HRID 1649921 の反応式
C(OC([NH:8][C@H:9]([C:16]([NH:18][C@H:19]([C@@H:27](O)[CH2:28][CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:17])[CH2:10][C:11]1[N:15]=[CH:14][NH:13][CH:12]=1)=O)(C)(C)C.FC(F)(F)C(O)=[O:37]>C(OCC)(=O)C>[NH2:8][C@H:9]([C:16]([NH:18][C@@H:19]([CH2:27][CH2:28][CH2:29][CH:30]([CH3:32])[CH3:31])[C@@H:20]([OH:37])[CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:17])[CH2:10][C:11]1[N:15]=[CH:14][NH:13][CH:12]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 178444654HCID 178444654、化合物

生成物 1

HCID 1784439352(S)-(L-histidyl)amino-1-cyclohexyl-(S)-hydroxy-6-methylheptane

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 2(S)-(N-t-butoxycarbonyl-L-histidyl)amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (383 mg) in trifluoroacetic acid (10 ml) was stirred at 0° C. for 30 minutes. After concentration of the mixture in vacuo, the residue was dissolved in ethyl acetate (20 ml). The solution was washed with saturated sodium bicarbonate solution, dried over magnesium sulfate, and concentrated in vacuo to give 2(S)-(L-histidyl)amino-1-cyclohexyl-(S)-hydroxy-6-methylheptane (275 mg) as an amorphous powder.

後処理

  1. washThe solution was washed with saturated sodium bicarbonate solution
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-25ae1cc3e60545f3a5d2f548485cefc4
出典データセット
uspto-grants-1990_05
特許番号
US04921855

反応ノート

読み込み中…