HCID 178444651、化合物 → HCID 178484308、化合物
反応式
[CH3:1][N:2]([C:14]([O:16][C@@H:17]([CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)[C:18]([N:20]([CH3:46])[C@H:21]([C:28]([NH:30][C@H:31]([C@@H:39]([OH:45])[CH2:40][CH2:41][CH:42]([CH3:44])[CH3:43])[CH2:32][CH:33]1[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1)=[O:29])[CH2:22][C:23]1[N:27]=[CH:26][NH:25][CH:24]=1)=[O:19])=[O:15])[CH2:3][CH2:4][N:5](C(OC(C)(C)C)=O)[CH3:6]>FC(F)(F)C(O)=O>[CH3:1][N:2]([C:14]([O:16][C@@H:17]([CH2:47][C:48]1[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=1)[C:18]([N:20]([CH3:46])[C@H:21]([C:28]([NH:30][C@H:31]([C@@H:39]([OH:45])[CH2:40][CH2:41][CH:42]([CH3:43])[CH3:44])[CH2:32][CH:33]1[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1)=[O:29])[CH2:22][C:23]1[N:27]=[CH:26][NH:25][CH:24]=1)=[O:19])=[O:15])[CH2:3][CH2:4][NH:5][CH3:6]参加物
3
実験手順
A solution of 2(S)-[Nα -[2(S)-[N-methyl-N-{2-(N-t-butoxycarbonyl-N-methylamino)ethyl}aminocarbonyloxy]-3-phenylpropionyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (114 mg) in trifluoroacetic acid (10 ml) was stirred at 0° C. for 1 hour. After evaporation of the solvent, the residue was dissolved in ethyl acetate (20 ml) and the solution was washed with 1M sodium bicarbonate solution and water successively, and dried over magnesium sulfate. Evaporation of the solvent gave 2(S)-[Nα -[2(S)-{N-methyl-N-(2-methylaminoethyl)aminocarbonyloxy}-3-phenylpropionyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (88 mg) as an amorphous powder.