Benzoic Acid → 5-Benzoylamino-1-hydroxy-5,6,7,8-tetrahydro-naphthalene

HRID 1649937ノート

反応式

HRID 1649937 の反応式
[C:1](O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ON1C2C=CC=CC=2N=N1.C1(N=C=NC2CCCCC2)CCCCC1.Br.[NH2:36][CH:37]1[CH2:46][CH2:45][CH2:44][C:43]2[C:42]([OH:47])=[CH:41][CH:40]=[CH:39][C:38]1=2.C(N(CC)CC)C>O1CCCC1>[C:1]([NH:36][CH:37]1[CH2:46][CH2:45][CH2:44][C:43]2[C:42]([OH:47])=[CH:41][CH:40]=[CH:39][C:38]1=2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 5

HCID 243Benzoic AcidHCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 198554515-Amino-1-hydroxy-5,6,7,8-tetrahydro-naphthalene hydrobromide

生成物 1

HCID 140149555-Benzoylamino-1-hydroxy-5,6,7,8-tetrahydro-naphthalene

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

50 mmol of benzoic acid and 50 mmol of 1-hydroxybenzotriazole (HOBT) are taken in 200 ml of absolute tetrahydrofuran at 0° C. 55 mmol of dicyclohexylcarbodiimide (DCC) are added under N2 and the mixture is stirred at 0° C. for 1 hour and then at room temperature for 1 hour. 50 mmol of 5-amino-1-hydroxy-5,6,7,8-tetrahydro-naphthalene hydrobromide and 50 mmol of triethylamine are added to this solution and the mixture is stirred at room temperature for 6 hours.

後処理

  1. waitat room temperature for 1 hour
  2. stirringthe mixture is stirred at room temperature for 6 hours

出典と根拠

ORDレコード
ord-f0a606568b2940ae8319a328946e32b7
出典データセット
uspto-grants-1990_05
特許番号
US04921998

反応ノート

読み込み中…