Boron trifluoride etherate → Ethyl 4-(mercaptomethyl)-2-methyl-1,3-dithiolane-2-propanoate

HRID 1650248ノート

反応式

HRID 1650248 の反応式
[SH:1][CH2:2][CH:3]([SH:6])[CH2:4][SH:5].[C:7]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:8][CH2:9][C:10]([CH3:12])=O.B(F)(F)F.CCOCC>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[CH2:4][S:5][C:10]([CH3:12])([CH2:9][CH2:8][C:7]([O:14][CH2:15][CH3:16])=[O:13])[S:6]1

参加物

5

反応物 3

HCID 8000Boron trifluoride etherateHCID 10883Ethyl levulinateHCID 784951,2,3-Propanetrithiol

生成物 1

HCID 14405950Ethyl 4-(mercaptomethyl)-2-methyl-1,3-dithiolane-2-propanoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared according to the procedure of Example 1 using 1,2,3-trimercaptopropane (5.6 g, 0.04 mol), ethyl levulinate (5.8 g, 0.04 mol) and boron trifluoride etherate (1.25 ml) in methylene chloride (150 ml). The crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent to give 3.35 g (31%) of product.

後処理

  1. customThe crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent

出典と根拠

ORDレコード
ord-7cc069acdfad4109be4f3cc6cd629c36
出典データセット
uspto-grants-1990_05
特許番号
US04923891

反応ノート

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