Hydrogen Bromide → 2-(4-Chlorobenzyl)-4-hydroxy-7-methylbenzimidazole hydrobromide

反応式

[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][C:7]2[NH:8][C:9]3[C:15]([O:16]C)=[CH:14][CH:13]=[C:12]([CH3:18])[C:10]=3[N:11]=2)=[CH:4][CH:3]=1.[BrH:21]>>[BrH:21].[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][C:7]2[NH:8][C:9]3[C:15]([OH:16])=[CH:14][CH:13]=[C:12]([CH3:18])[C:10]=3[N:11]=2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 260Hydrogen Bromide

HCID 139713472-(4-Chlorobenzyl)-4-methoxy-7-methylbenzimidazole

生成物 1

HCID 230523862-(4-Chlorobenzyl)-4-hydroxy-7-methylbenzimidazole hydrobromide

実験手順

A suspension of 2-(4-chlorobenzyl)-4-methoxy-7-methylbenzimidazole (4.0 g) in 48% aqueous hydrobromic acid (400 ml) under nitrogen was heated at 130° for 5 h, then evaporated to dryness in vacuo. The residue was recrystallized from ethanol-ether to afford the title compound (3.95 g), m.p. 275°-277° C.

後処理

temperaturewas heated at 130° for 5 h
customevaporated to dryness in vacuo
customThe residue was recrystallized from ethanol-ether

出典と根拠

ORDレコード: ord-5bb703b84ccb489d9ad50685be3b4537
出典データセット: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04925853

反応ノート

読み込み中…

参加物